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Mutation Information
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Mutation Site
|
R80A |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
Vpr |
Literature Information
|
PubMed PMID
|
17559673
|
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Published Year
|
2007 |
|
Journal
|
Virology journal |
|
Title
|
HIV-1 Vpr activates the G2 checkpoint through manipulation of the ubiquitin proteasome system. |
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Author
|
DeHart JL,Zimmerman ES,Ardon O,Monteiro-Filho CM,Argañaraz ER,Planelles V |
|
Evidence
|
The carboxy-terminal domain Vpr(R80A) mutant, which is able to bind DCAF1, is inactive in checkpoint activation and has dominant-negative character.
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HIV Mutation Detail Information