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Mutation Information
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Mutation Site
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R80A |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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Vpr |
Literature Information
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PubMed PMID
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33648539
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Published Year
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2021 |
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Journal
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Virology journal |
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Title
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HIV-1 Vpr activates host CRL4-DCAF1 E3 ligase to degrade histone deacetylase SIRT7. |
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Author
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Zhou X,Monnie C,DeLucia M,Ahn J |
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Evidence
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Cell cycle analyses of HEK293T cells transfected with the Vpr mutant that is deficient for DCAF1-binding (R62D/F69A) or Vpr C-terminal mutants (residue 1-79, and R80A) confirmed this model (Fig. 5a, lower panels).
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HIV Mutation Detail Information