|
Mutation Information
|
Mutation Site
|
S119T |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
IN |
|
Relevant Drug
|
INSTIs |
|
Country
|
italy |
Literature Information
|
PubMed PMID
|
32450199
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2020 |
|
Journal
|
International journal of antimicrobial agents |
|
Title
|
Susceptibility to HIV-1 integrase strand transfer inhibitors (INSTIs) in highly treatment-experienced patients who failed an INSTI-based regimen. |
|
Author
|
Santoro MM,Fornabaio C,Malena M,Galli L,Poli A,Menozzi M,Zazzi M,White KL,Castagna A,PRESTIGIO Study Group. |
|
Evidence
|
Two isolates contained L74M, E138K, G140S and Q148H, or L74M, T97A, S119T, E138K, G140S, Y143R and Q148H, and had high-level resistance to all INSTIs, including BIC and DTG.
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HIV Mutation Detail Information