|
Mutation Information
|
Mutation Site
|
S149K |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
CA |
Literature Information
|
PubMed PMID
|
31440231
|
|
Published Year
|
2019 |
|
Journal
|
Frontiers in microbiology |
|
Title
|
Role for Gag-CA Interdomain Linker in Primate Lentiviral Replication. |
|
Author
|
Doi N,Koma T,Adachi A,Nomaguchi M |
|
Evidence
|
Mutant S149N could grow albeit poorly in target lymphocytic cells, but mutants S149A, S149D, and S149K did not grow at all. Consistently, S149N exhibited normal early single-cycle infectivity in indicator cells but was partially defective for virus production (late replication phase).
|
|
|
HIV Mutation Detail Information