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Mutation Information
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Mutation Site
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S153Y |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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IN |
Literature Information
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PubMed PMID
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18687142
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Published Year
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2008 |
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Journal
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Retrovirology |
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Title
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Natural variation of HIV-1 group M integrase: implications for a new class of antiretroviral inhibitors. |
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Author
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Rhee SY,Liu TF,Kiuchi M,Zioni R,Gifford RJ,Holmes SP,Shafer RW |
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Evidence
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Among the CCD mutations shown to directly reduce raltegravir or elvitegravir susceptibility - H51Y, T66I, E92Q, F121Y, G140S, Y143C/H/R, Q146P, S147G, Q148H/R/K, S153Y, N155H/S, and E157Q - only positions 153 and 157 are polymorphic (prevalence >= 0.5%) with S153A and E157Q each present in 1% of sequences (Figures 1).
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HIV Mutation Detail Information