HBV Mutation Detail Information

> S184G Search Result

Mutation Information

Mutation Site	S184G
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Genotype/Subtype	D
Relevant Drug	entecavir (ETV)

Literature Information

PubMed PMID	15328117
Disease	Chronic hepatitis B
Published Year	2004
Journal	Antimicrobial agents and chemotherapy
Title	Clinical emergence of entecavir-resistant hepatitis B virus requires additional substitutions in virus already resistant to Lamivudine.
Author	Tenney DJ,Levine SM,Rose RE,Walsh AW,Weinheimer SP,Discotto L,Plym M,Pokornowski K,Yu CF,Angus P,Ayres A,Bartholomeusz A,Sievert W,Thompson G,Warner N,Locarnini S,Colonno RJ
Evidence	An HBV recombinant containing the RT domain with substitutions rtS184G and rtS202I from the week 92 patient B sample was >1,000-fold less susceptible to ETV than the reconstructed wt HBV recombinant (Tables (Tables33 and and4).4).

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation