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Mutation Information
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Mutation Site
|
S283G |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
IN |
|
Viral Reference
|
K03455.1
|
|
Relevant Drug
|
INSTIs |
|
Country
|
Russia |
Literature Information
|
PubMed PMID
|
32752001
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2020 |
|
Journal
|
Viruses |
|
Title
|
Genetic Features of HIV-1 Integrase Sub-Subtype A6 Predominant in Russia and Predicted Susceptibility to INSTIs. |
|
Author
|
Kirichenko A,Lapovok I,Baryshev P,van de Vijver DAMC,van Kampen JJA,Boucher CAB,Paraskevis D,Kireev D |
|
Evidence
|
Five of them (R20K, I72V, L74I, S119P, and V201I) were described as INSTI resistant. Remarkably, the prevalence of 12 polymorphic mutations (K14R, R20K, L74I, S119P, T124S, T124A, V126F, G134N, T218I, L234I, S255N, and S283G) was significantly different between sub-subtypes A6 and A1.
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HIV Mutation Detail Information