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Mutation Information
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Mutation Site
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S31A |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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X |
Literature Information
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PubMed PMID
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30358169
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Published Year
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2018 |
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Journal
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Cancer medicine |
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Title
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14-3-3ζ binds to hepatitis B virus protein X and maintains its protein stability in hepatocellular carcinoma cells. |
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Author
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Tang Y,Zhang Y,Wang C,Sun Z,Li L,Dong J,Zhou W |
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Evidence
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By performing Co-IP assay in HBV-free Huh7 cells expressing wild-type HBx, mutant HBx-S31A, or HBx-S31D (serine(31) was mutated into alanine(31) or aspartic acid(31) ), we found that the phosphorylated serine(31) with its near amino acid residues constituted a RPLphosphoS(31) GP (R, arginine; P, proline; L, leucine; S, serine; G, glycine) motif in HBx for 14-3-3zeta docking.
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HBV Mutation Detail Information