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Mutation Information
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Mutation Site
|
S31R |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
E7 |
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Combined Mutation
|
e7.S31R+e7.S32P |
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Genotype/Subtype
|
HPV16 |
Literature Information
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PubMed PMID
|
27829177
|
|
Published Year
|
2017 |
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Journal
|
Virology |
|
Title
|
A naturally occurring variant of HPV-16 E7 exerts increased transforming activity through acquisition of an additional phospho-acceptor site. |
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Author
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Zine El Abidine A,Tomaić V,Bel Haj Rhouma R,Massimi P,Guizani I,Boubaker S,Ennaifer E,Banks L |
|
Evidence
|
In one, we incorporated the N29S amino acid change in the context of the previously described E7 mutant S31R/S32P which destroys the CKII phospho-acceptor site (Barbosa et al., 1990), and in the other we incorporated the D21N change in the same context.
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HPV Mutation Detail Information