|
Mutation Information
|
Mutation Site
|
S375N |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
Gp120 |
|
Genotype/Subtype
|
B |
|
Relevant Drug
|
fostemsavir |
|
Country
|
Italy |
Literature Information
|
PubMed PMID
|
32464638
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2020 |
|
Journal
|
The Journal of antimicrobial chemotherapy |
|
Title
|
In vitro susceptibility to fostemsavir is not affected by long-term exposure to antiviral therapy in MDR HIV-1-infected patients. |
|
Author
|
Saladini F,Giannini A,Giammarino F,Maggiolo F,Vichi F,Corbelli GM,Galli A,Bigoloni A,Poli A,Santoro MM,Zazzi M,Castagna A |
|
Evidence
|
Among 23/24 gp120 sequences obtained, temsavir resistance-associated mutations (RAMs) were detected in three cases (two M426L and one S375N).
|
|
|
HIV Mutation Detail Information