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Mutation Information
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Mutation Site
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S375W |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
Env |
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Genotype/Subtype
|
B |
Literature Information
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PubMed PMID
|
32521274
|
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Published Year
|
2020 |
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Journal
|
Cell reports |
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Title
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Slow Receptor Binding of the Noncytopathic HIV-2UC1 Envs Is Balanced by Long-Lived Activation State and Efficient Fusion Activity. |
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Author
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Harris M,Ratnapriya S,Chov A,Cervera H,Block A,Gu C,Talledge N,Mansky LM,Sodroski J,Herschhorn A |
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Evidence
|
Moreover, increasing the binding affinity of HIV-1JRFL to sCD4 by introducing the S375W change, which shifts the Env conformation or conformations closer to that of the CD4-bound state, did not result in higher fusion activity.
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HIV Mutation Detail Information