|
Mutation Information
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Mutation Site
|
S57R |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
Tat |
Literature Information
|
PubMed PMID
|
30824746
|
|
Published Year
|
2019 |
|
Journal
|
Scientific reports |
|
Title
|
A Naturally Occurring Polymorphism in the HIV-1 Tat Basic Domain Inhibits Uptake by Bystander Cells and Leads to Reduced Neuroinflammation. |
|
Author
|
Ruiz AP,Ajasin DO,Ramasamy S,DesMarais V,Eugenin EA,Prasad VR |
|
Evidence
|
Transactivation by Tat-B was significantly reduced by R57S substitution, while that of Tat-C was enhanced by the reciprocal S57R substitution.
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HIV Mutation Detail Information