HIV Mutation Detail Information

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Mutation Information

Mutation Site	S68A
Mutation Type	Amino acid level
Gene/Protein/Region Type	Tat
Combined Mutation	tat.T68A+tat.T64A+tat.S62A

Literature Information

PubMed PMID	15737233
Published Year	2005
Journal	Virology journal
Title	Phosphorylation of HIV Tat by PKR increases interaction with TAR RNA and enhances transcription.
Author	Endo-Munoz L,Warby T,Harrich D,McMillan NA
Evidence	However, the percentage of phosphorylation at 15 minutes for the other double mutants and for the triple mutant decreased to 68% for Tat T64A.S68A, 48% for Tat S62A.S68A, and 56% for Tat S62A.T64A.S68A. These values also correlated well with the higher Pmax values (172.8%, 256.8% and 189.7% respectively) and K0.5 values (54.9 min, 109.7 min and 62.2 min respectively) for each mutant, indicating slower, less efficient and non-specific phosphorylation.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation