HBV Mutation Detail Information

> T109L Search Result

Mutation Information

Mutation Site	T109L
Mutation Type	Amino acid level
Gene/Protein/Region Type	C
Genotype/Subtype	A
Viral Reference	X02763
Country	Asia‐Pacific;Europe

Literature Information

PubMed PMID	32579776
Disease	Chronic hepatitis B
Published Year	2020
Journal	Journal of viral hepatitis
Title	Virology analysis of chronic hepatitis B virus-infected patients treated for 28 days with JNJ-56136379 monotherapy.
Author	Verbinnen T,Hodari M,Talloen W,Berke JM,Blue D,Yogaratnam J,Vandenbossche J,Shukla U,De Meyer S,Lenz O
Evidence	In line with the lack of in vitro resistance of these substitutions for JNJ‐6379 (FC of 1.2, 0.5 and 0.1 for T109M, I105L and T109L, respectively), both patients showed pronounced declines in HBV DNA of 3.18 and 3.38 log10 IU/mL (patients #5 and #7, Figure 2E and 2C and Table 2).

Contents
Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation