|
Mutation Information
|
Mutation Site
|
T143M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
S |
|
Genotype/Subtype
|
B;C |
|
Viral Reference
|
AP011097.1;
M54923.1 |
|
Country
|
Indonesia |
Literature Information
|
PubMed PMID
|
21063484
|
|
Disease
|
Occult HBV infection
|
|
Published Year
|
2010 |
|
Journal
|
Hepatology international |
|
Title
|
Occult hepatitis B in blood donors in Indonesia: altered antigenicity of the hepatitis B virus surface protein. |
|
Author
|
Thedja MD,Roni M,Harahap AR,Siregar NC,Ie SI,Muljono DH |
|
Evidence
|
Seven of the viremic samples had nucleotide substitutions (A521G, A551T, C582T, and A562G) in the S gene, causing amino acid mutations (T123A, M133L, and T143M) in the 'a' determinant of HBsAg that resulted in changes in the predicted antigenicity.
|
|
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HBV Mutation Detail Information