HBV Mutation Detail Information

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Mutation Information

Mutation Site	T147A
Mutation Type	Amino acid level
Gene/Protein/Region Type	C

Literature Information

PubMed PMID	19327810
Published Year	2009
Journal	Virology
Title	Chimeric constructs between two hepatitis B virus genomes confirm transcriptional impact of core promoter mutations and reveal multiple effects of core gene mutations.
Author	Tsai A,Kawai S,Kwei K,Gewaily D,Hutter A,Tong DR,Li J,Wands JR,Tong S
Evidence	This finding, together with the results of the mapping experiments, establishes that amino acid substitutions at the N-terminus of the 2A core protein (A36Tor G63V) reduce the stringency of virion secretion, whereas amino acid changes at the C-terminus of the 4B core protein (T147A, R151C, D153G, or Q179K) enhance genome maturity of secreted virions.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation