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Mutation Information
|
Mutation Site
|
T2045A |
|
Mutation Type
|
Nucleotide level |
|
Gene/Protein/Region Type
|
C |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
19664630
|
|
Disease
|
Hepatocellular carcinoma
|
|
Published Year
|
2009 |
|
Journal
|
Gastroenterology |
|
Title
|
Hepatitis B virus core variants modify natural course of viral infection and hepatocellular carcinoma progression. |
|
Author
|
Sung FY,Jung CM,Wu CF,Lin CL,Liu CJ,Liaw YF,Tsai KS,Yu MW |
|
Evidence
|
The longitudinal study further showed that the appearance of 2 such variants (T1938C and T2045A) was preceded by long-term diminished viral load and decreased rate of liver abnormalities and was significantly less frequent in individuals with a prolonged immune clearance phase that associated with spectrum of liver disease than those in inactive carrier or reactivation phase.
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HBV Mutation Detail Information