HIV Mutation Detail Information

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Mutation Information

Mutation Site	T215F
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Relevant Drug	tenofovir alafenamide (TAF);tenofovir (TFV)
Country	African heritage;Hispanic;Latino;Asian

Literature Information

PubMed PMID	31988104
Disease	HIV infection/AIDS
Published Year	2020
Journal	Antimicrobial agents and chemotherapy
Title	Antiviral Activity of Tenofovir Alafenamide against HIV-1 with Thymidine Analog-Associated Mutations and M184V.
Author	Margot N,Ram R,Abram M,Haubrich R,Callebaut C
Evidence	Resistance levels were higher for patient-derived viruses compared to SDMs, likely as a result of the choice of samples used to generate the patient-derived isolates, most of which containing TAMs associated with higher levels of resistance to TFV (M41L, L210W, and T215Y).

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation