|
Mutation Information
|
Mutation Site
|
T215Y |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
NRTIs;zidovudine (AZT) |
Literature Information
|
PubMed PMID
|
16207371
|
|
Published Year
|
2005 |
|
Journal
|
AIDS research and therapy |
|
Title
|
HIV-1 reverse transcriptase mutations that confer decreased in vitro susceptibility to anti-RT DNA aptamer RT1t49 confer cross resistance to other anti-RT aptamers but not to standard RT inhibitors. |
|
Author
|
Fisher TS,Joshi P,Prasad VR |
|
Evidence
|
Variants of HIV-1 RT shown to confer resistance to AZT (T215Y/M41L) and ddI and ddC (L74V) were sensitive to inhibition by RT1t49 (Table 3).
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HIV Mutation Detail Information