|
Mutation Information
|
Mutation Site
|
T218I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
IN |
|
Genotype/Subtype
|
CRF02_AG |
|
Relevant Drug
|
INSTIs |
|
Country
|
Cameroon |
Literature Information
|
PubMed PMID
|
33892628
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2021 |
|
Journal
|
BMC infectious diseases |
|
Title
|
Interaction analysis of statistically enriched mutations identified in Cameroon recombinant subtype CRF02_AG that can influence the development of Dolutegravir drug resistance mutations. |
|
Author
|
Mikasi SG,Isaacs D,Chitongo R,Ikomey GM,Jacobs GB,Cloete R |
|
Evidence
|
The consensus sequences generated using the database-derived HIV-1 CRF02_AG sequences (n = 287) and cohort sequences (n = 20), identified 20 naturally occurring polymorphisms (NOPS): E11D,K14R, V31I, M50I, I72V, L74MVI, L101I, T112V, T124A, G134N, I135V, K136K/Q, V201I, T206S, T218I, L234I, A265V, R269K, S283G (Fig. 2).
|
|
|
HIV Mutation Detail Information