HBV Mutation Detail Information

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Mutation Information

Mutation Site	T301A
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Genotype/Subtype	C
Viral Reference	GQ872210
Relevant Drug	tenofovir
Country	Korea

Literature Information

PubMed PMID	33562603
Disease	Chronic hepatitis B
Published Year	2021
Journal	International journal of molecular sciences
Title	Distinctive HBV Replication Capacity and Susceptibility to Tenofovir Induced by a Polymerase Point Mutation in Hepatoma Cell Lines and Primary Human Hepatocytes.
Author	Lee AR,Cho JY,Kim JC,Dezhbord M,Choo SY,Ahn CH,Kim NY,Shin JJ,Park S,Park ES,Won J,Kim DS,Lee JH,Kim KH
Evidence	Since the rtT301A mutation has not been reported yet, we investigated the role of this naturally occurring mutation on the viral replication and susceptibility to tenofovir in various liver cells (hepatoma cells as well as primary human hepatocytes).

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation