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Mutation Information
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Mutation Site
|
T35A |
|
Mutation Type
|
Nucleotide level |
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Gene/Protein/Region Type
|
RT |
Literature Information
|
PubMed PMID
|
17644816
|
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Published Year
|
2007 |
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Journal
|
Nucleic acids research |
|
Title
|
Active site binding and sequence requirements for inhibition of HIV-1 reverse transcriptase by the RT1 family of single-stranded DNA aptamers. |
|
Author
|
Kissel JD,Held DM,Hardy RW,Burke DH |
|
Evidence
|
Mutation C34A increased the IC50 to 100 +- 35 nM, mutation T35A increased the IC50 to 228 +- 96 nM and the combination mutation of C34A/T35A increased the IC50 to >500 nM.
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HIV Mutation Detail Information