|
Mutation Information
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Mutation Site
|
T4228C |
|
Mutation Type
|
Nucleotide level |
|
Gene/Protein/Region Type
|
NCR2 |
|
Genotype/Subtype
|
HPV16 |
|
Viral Reference
|
K02718.1
|
|
Country
|
India |
Literature Information
|
PubMed PMID
|
23762404
|
|
Disease
|
Cervical carcinoma;
Squamous-cell carcinoma
|
|
Published Year
|
2013 |
|
Journal
|
PloS one |
|
Title
|
Differential expression of HPV16 L2 gene in cervical cancers harboring episomal HPV16 genomes: influence of synonymous and non-coding region variations. |
|
Author
|
Mandal P,Bhattacharjee B,Das Ghosh D,Mondal NR,Roy Chowdhury R,Roy S,Sengupta S |
|
Evidence
|
Additionally, majority of E variant isolates within cases (54/57; 94.7%) portrayed a variation (T4228C) within the short non-coding region (NCR2) between E5 and L2 genes, which portrays a weak promoter activity specific for L2 mRNA expression.
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HPV Mutation Detail Information