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Mutation Information
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Mutation Site
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T427N |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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Gag |
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Immune Escape
|
Y |
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Relevant Drug
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NNRTIs |
Literature Information
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PubMed PMID
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29970102
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Published Year
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2018 |
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Journal
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Retrovirology |
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Title
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CD8+ T cells specific for conserved, cross-reactive Gag epitopes with strong ability to suppress HIV-1 replication. |
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Author
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Murakoshi H,Zou C,Kuse N,Akahoshi T,Chikata T,Gatanaga H,Oka S,Hanke T,Takiguchi M |
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Evidence
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The HLA-B*40:02-associated mutation in Gag T427N (p = 1.0 x 10-9, q = 3.2 x 10-6) was found within the TL8/HLA-B*40:02 epitope, suggesting that this mutation represented an escape from CD8+ T-cell recognition.
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HIV Mutation Detail Information