|
Mutation Information
|
Mutation Site
|
V106A |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.V106A+rt.F227L |
|
Relevant Drug
|
NNRTIs |
Literature Information
|
PubMed PMID
|
32712537
|
|
Published Year
|
2020 |
|
Journal
|
European journal of medicinal chemistry |
|
Title
|
Bioisosterism-based design and enantiomeric profiling of chiral hydroxyl-substituted biphenyl-diarylpyrimidine nonnucleoside HIV-1 reverse transcriptase inhibitors. |
|
Author
|
Chen X,Ding L,Tao Y,Pannecouque C,De Clercq E,Zhuang C,Chen FE |
|
Evidence
|
Toward double mutant virus strains (F227L + V106A, RES056), (S)-(-)-12a possessed submicromolar antiviral activities.
|
|
|
HIV Mutation Detail Information