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Mutation Information
|
Mutation Site
|
V131I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
X |
|
Combined Mutation
|
x.V131I+x.K130M |
Literature Information
|
PubMed PMID
|
25019072
|
|
Published Year
|
2014 |
|
Journal
|
Hepatobiliary surgery and nutrition |
|
Title
|
Hidden secret in hepatitis B viral X protein mutation and hypoxia-inducible factor-1α in hepatocarcinoma cancer. |
|
Author
|
Kim CH |
|
Evidence
|
The C-terminal region of amino acids 119-140 was important for the stability and transactivation, and the point mutations K130M/V131I enhance the functionality of HIF-1alpha, while C-terminal truncation diminish the HIF-1alpha function.
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HBV Mutation Detail Information