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Mutation Information
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Mutation Site
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V142I |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
Vif |
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Viral Reference
|
K02013.1
|
Literature Information
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PubMed PMID
|
30808702
|
|
Published Year
|
2019 |
|
Journal
|
mBio |
|
Title
|
HIV-1 Escape from Small-Molecule Antagonism of Vif. |
|
Author
|
Sharkey M,Sharova N,Mohammed I,Huff SE,Kummetha IR,Singh G,Rana TM,Stevenson M |
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Evidence
|
Here we show that resistance to these agents is dependent on an amino acid substitution in Vif (V142I) and on a point mutation that likely upregulates transcription by modifying the lymphocyte enhancing factor 1 (LEF-1) binding site.
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HIV Mutation Detail Information