|
Mutation Information
|
Mutation Site
|
V191I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Immune Escape
|
Y |
|
Relevant Drug
|
lamivudine (LAM) |
Literature Information
|
PubMed PMID
|
19098499
|
|
Disease
|
HBV-HIV coinfection
|
|
Published Year
|
2009 |
|
Journal
|
AIDS (London, England) |
|
Title
|
Molecular analysis of an HBsAg-negative hepatitis B virus mutant selected in a tenofovir-treated HIV-hepatitis B virus co-infected patient. |
|
Author
|
Amini-Bavil-Olyaee S,Sheldon J,Lutz T,Trautwein C,Tacke F |
|
Evidence
|
The molecular analysis performed in an HIV-hepatitis B virus (HBV) coinfected patient revealed selection of an unusual HBV polymerase mutation (rtV191I) during tenofovir-containing therapy, conferring simultaneously immune escape by HBsAg negativity and resistance to lamivudine but not tenofovir.
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|
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HBV Mutation Detail Information