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HIV Mutation Detail Information

> V32I Search Result


Mutation Information
Mutation Site V32I
Mutation Type Amino acid level
Gene/Protein/Region Type PR
Relevant Drug darunavir (DRV)
Literature Information
PubMed PMID 18808097
Published Year 2008
Journal Journal of medicinal chemistry
Title Solution kinetics measurements suggest HIV-1 protease has two binding sites for darunavir and amprenavir.
Author Kovalevsky AY,Ghosh AK,Weber IT
Evidence Solution Kinetics Measurements Suggest HIV-1 Protease Has Two Binding Sites for Darunavir and AmprenavirDarunavir, a potent antiviral drug, showed an unusual second binding site on the HIV-1 protease dimer surface of the V32I drug resistant mutant and normal binding in the active site cavity.
Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation