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Mutation Information
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Mutation Site
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V370A |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
Gag |
Literature Information
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PubMed PMID
|
33508465
|
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Published Year
|
2021 |
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Journal
|
Bioorganic & medicinal chemistry letters |
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Title
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Design and exploration of C-3 benzoic acid bioisosteres and alkyl replacements in the context of GSK3532795 (BMS-955176) that exhibit broad spectrum HIV-1 maturation inhibition. |
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Author
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Swidorski JJ,Jenkins S,Hanumegowda U,Parker DD,Beno BR,Protack T,Ng A,Gupta A,Shanmugam Y,Dicker IB,Krystal M,Meanwell NA,Regueiro-Ren A |
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Evidence
|
A cyclohexene carboxylic acid provided exceptional inhibition of wild-type, V370A and DeltaV370 mutant viruses in addition to a suitable PK profile following oral dosing to rats.
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HIV Mutation Detail Information