|
Mutation Information
|
Mutation Site
|
V458W |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
Env |
|
Combined Mutation
|
env.Y459Q+env.V458W |
|
Genotype/Subtype
|
B |
Literature Information
|
PubMed PMID
|
32521274
|
|
Published Year
|
2020 |
|
Journal
|
Cell reports |
|
Title
|
Slow Receptor Binding of the Noncytopathic HIV-2UC1 Envs Is Balanced by Long-Lived Activation State and Efficient Fusion Activity. |
|
Author
|
Harris M,Ratnapriya S,Chov A,Cervera H,Block A,Gu C,Talledge N,Mansky LM,Sodroski J,Herschhorn A |
|
Evidence
|
Nevertheless, introducing these changes (E182V, T266A, N337K, and V458W+Y459Q) into HIV-2UC1 did not significantly affect the general pattern of infectivity and sCD4 sensitivity (data not shown).
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HIV Mutation Detail Information