|
Mutation Information
|
Mutation Site
|
V539I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
Literature Information
|
PubMed PMID
|
10762559
|
|
Clinical information
|
Yes
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2000 |
|
Journal
|
The Journal of infectious diseases |
|
Title
|
Evolution of hepatitis B virus polymerase gene sequence during famciclovir therapy for chronic hepatitis B. |
|
Author
|
Seignères B,Pichoud C,Ahmed SS,Hantz O,Trépo C,Zoulim F |
|
Evidence
|
By contrast, the 2 other mutations, L528M and V539I, detected in responders 23 and 22, respectively, were still present after cessation of treatment, the first mutant as a mixture with wild-type viral genome and the second mutant present as a major variant.
|
|
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HBV Mutation Detail Information