Home
Virus
Gene
Disease
Dataset
Download
Help
 
HIV Mutation Detail Information

> V66A Search Result


Mutation Information
Mutation Site V66A
Mutation Type Amino acid level
Gene/Protein/Region Type Nef
Literature Information
PubMed PMID 22643973
Published Year 2012
Journal Journal of molecular modeling
Title Validation of a novel secretion modification region (SMR) of HIV-1 Nef using cohort sequence analysis and molecular modeling.
Author Campbell PE,Isayev O,Ali SA,Roth WW,Huang MB,Powell MD,Leszczynski J,Bond VC
Evidence Computational analysis including modeling of wild-type HIV-1 Nef and V66A Nef SMR mutant using structural homology and molecular dynamics of ligand-associated interactions indicated significant structural changes in the Nef mutant, thus supporting the importance of the SMR domain for mediating Nef vesicle secretion.
Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation