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Mutation Information
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Mutation Site
|
V82A |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
PR |
|
Genotype/Subtype
|
B |
|
Relevant Drug
|
fosamprenavir (FPV);indinavir (IDV);lopinavir (LPV);nelfinavir (NFV);saquinavir (SQV) |
Literature Information
|
PubMed PMID
|
30560871
|
|
Published Year
|
2018 |
|
Journal
|
Scientific reports |
|
Title
|
Characterizing early drug resistance-related events using geometric ensembles from HIV protease dynamics. |
|
Author
|
Sheik Amamuddy O,Bishop NT,Tastan Bishop Ö |
|
Evidence
|
Additional research on multi-drug resistant HIV protease further described an expanded active site pocket and cavity expansion due to atomic volume for the HIV protease mutants V82A and I84V.
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HIV Mutation Detail Information