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Mutation Information
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Mutation Site
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V82S |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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PR |
Literature Information
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PubMed PMID
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31172041
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Published Year
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2019 |
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Journal
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ACS omega |
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Title
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Highly Drug-Resistant HIV-1 Protease Mutant PRS17 Shows Enhanced Binding to Substrate Analogues. |
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Author
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Agniswamy J,Kneller DW,Brothers R,Wang YF,Harrison RW,Weber IT |
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Evidence
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The loss of beta-branched side chain by V82S mutation initiates a shift in 80's loop and reshapes the S3/S3' subsite, which enhances substrate binding with new hydrogen bonds and van der Waals interactions that are absent in the wild-type structures.
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HIV Mutation Detail Information