HIV Mutation Detail Information

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Mutation Information

Mutation Site	V90I
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Relevant Drug	NNRTIs
Country	South Africa

Literature Information

PubMed PMID	32071061
Disease	HIV infection/AIDS
Published Year	2020
Journal	Antimicrobial agents and chemotherapy
Title	Discordance between Etravirine Phenotype and Genotype-Based Predicted Phenotype for Subtype C HIV-1 from First-Line Antiretroviral Therapy Failures in South Africa.
Author	McCormick KD,Penrose KJ,Brumme CJ,Harrigan PR,Viana RV,Mellors JW,Parikh UM,Wallis CL
Evidence	HIV-1 subtype C donor-derived viruses with V90I (P < 0.024) and V179D (P < 0.007) also showed a trend toward increased ETR resistance, but when adjusted for multiple comparisons (q < 0.567 and q < 0.233, respectively), these were no longer significant.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation