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Mutation Information
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Mutation Site
|
W11F |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
Tat |
Literature Information
|
PubMed PMID
|
32210470
|
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Published Year
|
2020 |
|
Journal
|
PloS one |
|
Title
|
Morphine exposure exacerbates HIV-1 Tat driven changes to neuroinflammatory factors in cultured astrocytes. |
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Author
|
Chen K,Phan T,Lin A,Sardo L,Mele AR,Nonnemacher MR,Klase Z |
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Evidence
|
Tat variants containing mutations at this position, such as W11F or W11Y, are deficient in both secretion from Tat-producing cells and cytoplasmic translocation in recipient cells.
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HIV Mutation Detail Information