|
Mutation Information
|
Mutation Site
|
W172S |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
S |
|
Combined Mutation
|
s.W172S+rt.A181T |
|
Relevant Drug
|
adefovir (ADV);tenofovir (TDF) |
|
Country
|
Korea |
Literature Information
|
PubMed PMID
|
24696492
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2014 |
|
Journal
|
Journal of virology |
|
Title
|
The impact of the hepatitis B virus polymerase rtA181T mutation on replication and drug resistance is potentially affected by overlapping changes in surface gene. |
|
Author
|
Ahn SH,Park YK,Park ES,Kim JH,Kim DH,Lim KH,Jang MS,Choe WH,Ko SY,Sung IK,Kwon SY,Kim KH |
|
Evidence
|
Compared to the rtA181T surface missense mutation (rtA181T/sW172S), the introduction of rtA181T surface nonsense mutation (rtA181T/sW172*) resulted in decreased viral replication and increased drug resistance.
|
|
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HBV Mutation Detail Information