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Mutation Information
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Mutation Site
|
W196L |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
S |
|
Combined Mutation
|
s.W196L+s.E164D |
|
Immune Escape
|
Y |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
28300730
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2017 |
|
Journal
|
Antiviral therapy |
|
Title
|
The enrichment of HBV immune-escape mutations during nucleoside/nucleotide analogue therapy. |
|
Author
|
Shan M,Shen Z,Sun H,Zheng J,Zhang M |
|
Evidence
|
Three types of drug resistant mutations, single primary, multiple primary and primary plus compensatory mutations, were detected in a total of 97 patients of NAs treatment group, with rtM204I/V/S in YMDD motif being the most common substitution (78 of 97) (Table 2), which displays resistance to LMV and exerts sW196L/V and sI195M changes in the corresponding S protein.
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HBV Mutation Detail Information