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HIV Mutation Detail Information

> W235E Search Result


Mutation Information
Mutation Site W235E
Mutation Type Amino acid level
Gene/Protein/Region Type IN
Literature Information
PubMed PMID 33980829
Published Year 2021
Journal Nature communications
Title INI1/SMARCB1 Rpt1 domain mimics TAR RNA in binding to integrase to facilitate HIV-1 replication.
Author Dixit U,Bhutoria S,Wu X,Qiu L,Spira M,Mathew S,Harris R,Adams LJ,Cahill S,Pathak R,Rajesh Kumar P,Nguyen M,Acharya SA,Brenowitz M,Almo SC,Zou X,Steven AC,Cowburn D,Girvin M,Kalpana GV
Evidence Interestingly, previous reports have indicated that W235E and W235K, but not W235F substitution mutations selectively inhibit integration activity in vivo but not in vitro
Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation