HIV Mutation Detail Information

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Mutation Information

Mutation Site	W54R
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Country	Australia

Literature Information

PubMed PMID	17630831
Disease	HIV infection/AIDS
Published Year	2007
Journal	PLoS pathogens
Title	HIV-1 Vpr-mediated G2 arrest involves the DDB1-CUL4AVPRBP E3 ubiquitin ligase.
Author	Belzile JP,Duisit G,Rougeau N,Mercier J,Finzi A,Cohen EA
Evidence	Moreover, W54R, a mutant of Vpr that was previously shown to be defective for the interaction and degradation of uracil-DNA glycosylase (UNG2/CCNU), was still capable of associating with the DDB1-CUL4AVPRBPcomplex (Figure 6A, lane 4) and mediating G2 arrest (Figure 6C), suggesting that UNG2 and VPRBP bind to two distinct domains on Vpr.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation