|
Mutation Information
|
Mutation Site
|
Y132A |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
C |
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Genotype/Subtype
|
B |
Literature Information
|
PubMed PMID
|
26598693
|
|
Published Year
|
2015 |
|
Journal
|
Proceedings of the National Academy of Sciences of the United States of America |
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Title
|
High-resolution crystal structure of a hepatitis B virus replication inhibitor bound to the viral core protein. |
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Author
|
Klumpp K,Lam AM,Lukacs C,Vogel R,Ren S,Espiritu C,Baydo R,Atkins K,Abendroth J,Liao G,Efimov A,Hartman G,Flores OA |
|
Evidence
|
The compound NVR-010-001-E2 can induce assembly of the HBV core wild-type and Y132A mutant proteins and thermostabilize the proteins with a Tm increase of more than 10 degrees C.
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|
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HBV Mutation Detail Information