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Mutation Information
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Mutation Site
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Y132A |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
C |
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Genotype/Subtype
|
D |
Literature Information
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PubMed PMID
|
28205569
|
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Published Year
|
2017 |
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Journal
|
Scientific reports |
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Title
|
Heteroaryldihydropyrimidine (HAP) and Sulfamoylbenzamide (SBA) Inhibit Hepatitis B Virus Replication by Different Molecular Mechanisms. |
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Author
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Zhou Z,Hu T,Zhou X,Wildum S,Garcia-Alcalde F,Xu Z,Wu D,Mao Y,Tian X,Zhou Y,Shen F,Zhang Z,Tang G,Najera I,Yang G,Shen HC,Young JA,Qin N |
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Evidence
|
Interestingly, two reference compounds HAP_R01 and SBA_R01 bind to the same pocket at the dimer-dimer interface in the crystal structures of core protein Y132A hexamer.
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HBV Mutation Detail Information