|
Mutation Information
|
Mutation Site
|
Y181C |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.Y181C+rt.K103N;rt.Y181C+rt.V106A+rt.K103N;rt.G190A+rt.Y181C;rt.Y181C+rt.V106A |
|
Relevant Drug
|
nevirapine (NPV) |
|
Country
|
Uganda |
Literature Information
|
PubMed PMID
|
18684096
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2008 |
|
Journal
|
The Journal of infectious diseases |
|
Title
|
Analysis of nevirapine (NVP) resistance in Ugandan infants who were HIV infected despite receiving single-Dose (SD) NVP versus SD NVP plus daily NVP up to 6 weeks of age to prevent HIV vertical transmission. |
|
Author
|
Church JD,Omer SB,Guay LA,Huang W,Lidstrom J,Musoke P,Mmiro F,Jackson JB,Eshleman SH |
|
Evidence
|
We tested plasma HIV using a genotyping assay (ViroSeq), a phenotypic resistance assay (PhenoSense), and sensitive point mutation assay (LigAmp, for K103N, Y181C, G190A).
|
|
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HIV Mutation Detail Information