|
Mutation Information
|
Mutation Site
|
Y181C |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Genotype/Subtype
|
A;C;D;DA |
|
Relevant Drug
|
efavirenz (EFV);nevirapine (NPV) |
|
Country
|
Kenya |
Literature Information
|
PubMed PMID
|
27231099
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2016 |
|
Journal
|
Journal of the International AIDS Society |
|
Title
|
Treatment failure and drug resistance in HIV-positive patients on tenofovir-based first-line antiretroviral therapy in western Kenya. |
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Author
|
Brooks K,Diero L,DeLong A,Balamane M,Reitsma M,Kemboi E,Orido M,Emonyi W,Coetzer M,Hogan J,Kantor R |
|
Evidence
|
Mutations associated with K65R included Y181C (19/24, 79%, with K65R vs. 2/11, 18%, without;p=0.002); G190A/S (12/24, 50%, with K65R vs. 1/11, 9%, without;p=0.027);and G190A/Y181C co-occurrence (9/24, 38% with K65R vs. 0/11 without;p=0.033).
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HIV Mutation Detail Information