HIV Mutation Detail Information

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Mutation Information

Mutation Site	Y181C
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Relevant Drug	NNRTIs

Literature Information

PubMed PMID	30788976
Published Year	2019
Journal	Antiviral chemistry & chemotherapy
Title	Synthesis and anti-human immunodeficiency virus activity of substituted ( o,o-difluorophenyl)-linked-pyrimidines as potent non-nucleoside reverse transcriptase inhibitors.
Author	Čechová L,Dejmek M,Baszczyňski O,Šaman D,Gao L,Hu E,Stepan G,Jansa P,Janeba Z,Šimon P
Evidence	Antiviral activities of 20 compounds were measured against wild type human immunodeficiency virus-1 and mutant reverse transcriptase strains (K103N, Y181C) using a cytoprotection assay.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation