HIV Mutation Detail Information

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Mutation Information

Mutation Site	Y181C
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Combined Mutation	rt.Y181C+rt.K103N
Relevant Drug	NNRTIs

Literature Information

PubMed PMID	32640577
Published Year	2020
Journal	Viruses
Title	Targeting HIV-1 RNase H: N'-(2-Hydroxy-benzylidene)-3,4,5-Trihydroxybenzoylhydrazone as Selective Inhibitor Active against NNRTIs-Resistant Variants.
Author	Corona A,Ballana E,Distinto S,Rogolino D,Del Vecchio C,Carcelli M,Badia R,Riveira-Muñoz E,Esposito F,Parolin C,Esté JA,Grandi N,Tramontano E
Evidence	Here, we characterize the mode of action of N'-(2-hydroxy-benzylidene)-3,4,5-trihydroxybenzoylhydrazone (compound 13), an N-acylhydrazone derivative that inhibited viral replication (EC50 = 10 microM), while retaining full potency against the NNRTI-resistant double mutant K103N-Y181C virus.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation