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Mutation Information
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Mutation Site
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Y181C |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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RT |
Literature Information
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PubMed PMID
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32974670
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Published Year
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2021 |
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Journal
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The Journal of antimicrobial chemotherapy |
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Title
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In vitro cross-resistance to doravirine in a panel of HIV-1 clones harbouring multiple NNRTI resistance mutations. |
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Author
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Saladini F,Giammarino F,Hosseini BA,Giannini A,Boccuto A,Dragoni F,Vicenti I,Shafer RW,Zazzi M |
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Evidence
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METHODS: In vitro phenotypic susceptibility to doravirine was assessed in 10 clinically derived infectious clones with intermediate- to high-level resistance to rilpivirine, etravirine, efavirenz and nevirapine, and in NL4-3 site-directed mutants harbouring K103N, Y181C, M230L or K103N/Y181C NNRTI mutations.
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HIV Mutation Detail Information