EBV Mutation Detail Information

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Mutation Information

Mutation Site	Y384G
Mutation Type	Amino acid level
Gene/Protein/Region Type	LMP1

Literature Information

PubMed PMID	29134204
Published Year	2017
Journal	mSphere
Title	Latent Membrane Protein 1 Is a Novel Determinant of Epstein-Barr Virus Genome Persistence and Reactivation.
Author	Caves EA,Butch RM,Cook SA,Wasil LR,Chen C,Di YP,Lee N,Shair KHY
Evidence	Deletion of the PXQXT TRAF-binding motif in CTAR1 (ΔPXQXT), but not mutation of the CTAR2 residue (Y384G) critical for NF-κB activation, resulted in a more progressive loss of EBV genomes, stabilizing at a 90% loss by 46 days (Fig. 2a).

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation