HBV Mutation Detail Information

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Mutation Information

Mutation Site	Y6*
Mutation Type	Amino acid level
Gene/Protein/Region Type	C

Literature Information

PubMed PMID	18571815
Disease	Chronic hepatitis B
Published Year	2008
Journal	Hepatology (Baltimore, Md.)
Title	Defective hepatitis B virus DNA is not associated with disease status but is reduced by polymerase mutations associated with drug resistance.
Author	Preiss S,Littlejohn M,Angus P,Thompson A,Desmond P,Lewin SR,Sasadeusz J,Matthews G,Dore GJ,Shaw T,Sozzi V,Yuen L,Lau G,Ayres A,Thio C,Avihingsanon A,Ruxrungtham K,Locarnini S,Revill PA
Evidence	Similarly, a core mutant with a stop mutation in the core gene (coreY6*) did not produce HBV particles, although pgRNA and spliced RNA were detected, from both mutants, following their transcription from the input plasmid DNA.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation